Restlessness or agitation after Cyphenothrin + Fipronil + S-methoprene in dogs

The FDA has received 222 reports of restlessness or agitation in dogs after Cyphenothrin + Fipronil + S-methoprene. That is 34% of all reports for this medicine, compared with 1.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

222Reports

85%Marked serious

52%Recovered

0.0%Died or euthanised

11 daysTypical onset

How soon it started

Same day

54 38%

1–2 days

12 8.4%

3–7 days

4 2.8%

1–4 weeks

15 10%

Over a month

58 41%

How the animals did

Recovered

116 52%

Still unwell when reported

7 3.2%

Not known

99 45%

Problems reported at the same time

Itching

109 49%

Behaviour change

41 18%

Application site reaction

35 16%

34 15%

32 14%

25 11%

20 9.0%

12 5.4%

Age of the animals

Under 1 year

1–3 years

4–7 years

101

8–11 years

12+ years

About this medicine

Fipronil kills fleas and ticks (spot-on).

Questions owners ask

Can Cyphenothrin + Fipronil + S-methoprene cause restlessness or agitation in dogs?: 222 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 11 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Restlessness or agitation with similar medicines

Restlessness or agitation after Spinosad (Comfortis) 658 reports · 1.2% of its reports
Restlessness or agitation after Lufenuron + Milbemycin Oxime (Sentinel) 255 reports · 1.0% of its reports
Restlessness or agitation after Imidacloprid + Moxidectin (Advantage Multi) 835 reports · 6.4% of its reports
Restlessness or agitation after Nitenpyram (Capstar) 596 reports · 5.5% of its reports
Restlessness or agitation after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 73 reports · 0.7% of its reports
Restlessness or agitation after Fipronil + S-methoprene (Frontline Plus) 119 reports · 4.0% of its reports
Restlessness or agitation after Flumethrin + Imidacloprid (Seresto) 68 reports · 3.0% of its reports
Restlessness or agitation after Imidacloprid 44 reports · 2.3% of its reports
Restlessness or agitation after Fipronil 40 reports · 2.8% of its reports
Restlessness or agitation after Imidacloprid + Permethrin + Pyriproxyfen 56 reports · 7.6% of its reports

All reported side effects of Cyphenothrin + Fipronil + S-methoprene in dogs · Medicines most reported with restlessness or agitation