Tremors after Cyphenothrin + Fipronil + S-methoprene in dogs

42 reports to the FDA describe tremors in dogs given Cyphenothrin + Fipronil + S-methoprene. That is 6.5% of all reports for this medicine, compared with 3.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

42Reports

81%Marked serious

38%Recovered

0.0%Died or euthanised

4 daysTypical onset

How soon it started

Same day

11 37%

1–2 days

4 13%

3–7 days

3 10%

1–4 weeks

1 3.3%

Over a month

11 37%

How the animals did

Recovered

16 38%

Still unwell when reported

3 7.1%

Not known

23 55%

Problems reported at the same time

Restlessness or agitation

12 29%

12 29%

11 26%

7 17%

6 14%

6 14%

5 12%

4 9.5%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Fipronil kills fleas and ticks (spot-on).

Questions owners ask

Can Cyphenothrin + Fipronil + S-methoprene cause tremors in dogs?: 42 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 4 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Tremors with similar medicines

Tremors after Spinosad (Comfortis) 2,268 reports · 4.0% of its reports
Tremors after Lufenuron + Milbemycin Oxime (Sentinel) 590 reports · 2.3% of its reports
Tremors after Imidacloprid + Moxidectin (Advantage Multi) 837 reports · 6.4% of its reports
Tremors after Nitenpyram (Capstar) 402 reports · 3.7% of its reports
Tremors after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 213 reports · 2.1% of its reports
Tremors after Fipronil + S-methoprene (Frontline Plus) 141 reports · 4.8% of its reports
Tremors after Flumethrin + Imidacloprid (Seresto) 66 reports · 2.9% of its reports
Tremors after Imidacloprid 58 reports · 3.0% of its reports
Tremors after Fipronil 65 reports · 4.6% of its reports
Tremors after Lufenuron 33 reports · 3.2% of its reports

All reported side effects of Cyphenothrin + Fipronil + S-methoprene in dogs · Medicines most reported with tremors