Cyphenothrin + Fipronil + S-methoprene side effects in dogs
648 reports sent to the FDA between 2012 and 2026 involve Cyphenothrin + Fipronil + S-methoprene in dogs. The most reported problems were itching, restlessness or agitation, behaviour change. 77% were marked serious.
648Reports
77%Marked serious
0.0%Only medicine involved
44%Recovered
0.9%Died or euthanised
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About this medicine
Fipronil kills fleas and ticks (spot-on).
Most reported side effects
Share = percentage of this medicine's reports that mention the problem. One report can list several problems.
Reports that it didn't work
Some reports are about the medicine not working (for example a dog still getting fleas or heartworm), not about a side effect.
How soon problems started
Time from the first dose to the first sign, where both dates were reported (446 reports).
How the animals did
Breeds named most often
Popular breeds appear more often because there are more of them.
- Shih Tzu 73 reports
- Bichon Frise 34 reports
- Chihuahua 21 reports
- Maltese 21 reports
- Labrador Retriever 20 reports
- Toy Poodle 19 reports
- Yorkshire Terrier 18 reports
- Golden Retriever 17 reports
- Miniature Schnauzer 14 reports
- Dog (other) 13 reports
Other flea and tick treatments for dogs
Spinosad (Comfortis)57,095 reports · 7.7% seriousLufenuron + Milbemycin Oxime (Sentinel)26,051 reports · 24% seriousImidacloprid + Moxidectin (Advantage Multi)13,117 reports · 57% seriousNitenpyram (Capstar)10,782 reports · 10.0% seriousLufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum)9,966 reports · 40% seriousFipronil + S-methoprene (Frontline Plus)2,954 reports · 49% seriousFlumethrin + Imidacloprid (Seresto)2,273 reports · 25% seriousImidacloprid1,908 reports · 11% serious