Vomiting after Cyphenothrin + Fipronil + S-methoprene in dogs

The FDA has received 63 reports of vomiting in dogs after Cyphenothrin + Fipronil + S-methoprene. That is 9.7% of all reports for this medicine, compared with 28% across reports for all dog medicines, so it is reported less often than average with this medicine.

63Reports

79%Marked serious

56%Recovered

0.0%Died or euthanised

2 daysTypical onset

How soon it started

Same day

13 31%

1–2 days

10 24%

3–7 days

4 9.5%

1–4 weeks

1 2.4%

Over a month

14 33%

How the animals did

Recovered

33 52%

Recovered with lasting effects

2 3.2%

Still unwell when reported

2 3.2%

Not known

26 41%

Problems reported at the same time

Itching

15 24%

Diarrhea

13 21%

Lethargy

10 16%

Restlessness or agitation

8 13%

Breathing problems

6 9.5%

Loss of appetite

6 9.5%

Application site reaction

5 7.9%

Behaviour change

4 6.3%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Fipronil kills fleas and ticks (spot-on).

Questions owners ask

Can Cyphenothrin + Fipronil + S-methoprene cause vomiting in dogs?: 63 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 2 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vomiting with similar medicines

Vomiting after Spinosad (Comfortis) 30,909 reports · 54% of its reports
Vomiting after Lufenuron + Milbemycin Oxime (Sentinel) 4,725 reports · 18% of its reports
Vomiting after Imidacloprid + Moxidectin (Advantage Multi) 1,904 reports · 15% of its reports
Vomiting after Nitenpyram (Capstar) 1,204 reports · 11% of its reports
Vomiting after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 1,925 reports · 19% of its reports
Vomiting after Fipronil + S-methoprene (Frontline Plus) 627 reports · 21% of its reports
Vomiting after Flumethrin + Imidacloprid (Seresto) 295 reports · 13% of its reports
Vomiting after Imidacloprid 251 reports · 13% of its reports
Vomiting after Fipronil 417 reports · 30% of its reports
Vomiting after Lufenuron 325 reports · 32% of its reports

All reported side effects of Cyphenothrin + Fipronil + S-methoprene in dogs · Medicines most reported with vomiting