Vocalising after Fipronil in dogs

28 reports to the FDA describe vocalising in dogs given Fipronil. That is 2.0% of all reports for this medicine, compared with 1.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

28Reports

46%Marked serious

54%Recovered

7.1%Died or euthanised

22 daysTypical onset

How soon it started

Same day

2 13%

1–2 days

3 20%

3–7 days

0 0.0%

1–4 weeks

3 20%

Over a month

7 47%

How the animals did

Recovered

14 50%

Recovered with lasting effects

1 3.6%

Still unwell when reported

7 25%

Died

1 3.6%

Euthanised

1 3.6%

Not known

4 14%

Problems reported at the same time

Vomiting

8 29%

Lethargy

7 25%

Diarrhea

6 21%

Restlessness or agitation

6 21%

Behaviour change

6 21%

Loss of appetite

6 21%

Itching

4 14%

Abnormal radiograph finding

3 11%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Fipronil kills fleas and ticks (spot-on).

Questions owners ask

Can Fipronil cause vocalising in dogs?: 28 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 22 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vocalising with similar medicines

Vocalising after Spinosad (Comfortis) 586 reports · 1.0% of its reports
Vocalising after Lufenuron + Milbemycin Oxime (Sentinel) 180 reports · 0.7% of its reports
Vocalising after Imidacloprid + Moxidectin (Advantage Multi) 295 reports · 2.2% of its reports
Vocalising after Nitenpyram (Capstar) 262 reports · 2.4% of its reports
Vocalising after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 45 reports · 0.5% of its reports
Vocalising after Fipronil + S-methoprene (Frontline Plus) 67 reports · 2.3% of its reports
Vocalising after Flumethrin + Imidacloprid (Seresto) 53 reports · 2.3% of its reports
Vocalising after Imidacloprid 46 reports · 2.4% of its reports
Vocalising after Imidacloprid + Permethrin + Pyriproxyfen 29 reports · 3.9% of its reports
Vocalising after Cyphenothrin + Fipronil + S-methoprene 55 reports · 8.5% of its reports

All reported side effects of Fipronil in dogs · Medicines most reported with vocalising