Vocalising after Fipronil + S-methoprene (Frontline Plus) in dogs

67 reports to the FDA describe vocalising in dogs given Fipronil + S-methoprene. That is 2.3% of all reports for this medicine, compared with 1.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

67Reports

55%Marked serious

45%Recovered

3.0%Died or euthanised

21 daysTypical onset

How soon it started

Same day

7 14%

1–2 days

9 18%

3–7 days

2 4.0%

1–4 weeks

11 22%

Over a month

21 42%

How the animals did

Recovered

29 43%

Recovered with lasting effects

1 1.5%

Still unwell when reported

7 10%

Died

1 1.5%

Euthanised

1 1.5%

Not known

28 42%

Problems reported at the same time

Vomiting

16 24%

Behaviour change

14 21%

Breathing problems

13 19%

Restlessness or agitation

13 19%

12 18%

11 16%

9 13%

8 12%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Fipronil kills fleas and ticks (spot-on).

Products with this combination include Frontline Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Fipronil + S-methoprene cause vocalising in dogs?: 67 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 21 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vocalising with similar medicines

Vocalising after Spinosad (Comfortis) 586 reports · 1.0% of its reports
Vocalising after Lufenuron + Milbemycin Oxime (Sentinel) 180 reports · 0.7% of its reports
Vocalising after Imidacloprid + Moxidectin (Advantage Multi) 295 reports · 2.2% of its reports
Vocalising after Nitenpyram (Capstar) 262 reports · 2.4% of its reports
Vocalising after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 45 reports · 0.5% of its reports
Vocalising after Flumethrin + Imidacloprid (Seresto) 53 reports · 2.3% of its reports
Vocalising after Imidacloprid 46 reports · 2.4% of its reports
Vocalising after Fipronil 28 reports · 2.0% of its reports
Vocalising after Imidacloprid + Permethrin + Pyriproxyfen 29 reports · 3.9% of its reports
Vocalising after Cyphenothrin + Fipronil + S-methoprene 55 reports · 8.5% of its reports

All reported side effects of Fipronil + S-methoprene in dogs · Medicines most reported with vocalising