Vocalising after Imidacloprid + Moxidectin (Advantage Multi) in dogs

295 reports to the FDA describe vocalising in dogs given Imidacloprid + Moxidectin. That is 2.2% of all reports for this medicine, compared with 1.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

295Reports

60%Marked serious

38%Recovered

6.4%Died or euthanised

Same dayTypical onset

How soon it started

Same day

119 56%

1–2 days

40 19%

3–7 days

15 7.1%

1–4 weeks

22 10%

Over a month

15 7.1%

How the animals did

Recovered

111 38%

Recovered with lasting effects

1 0.3%

Still unwell when reported

11 3.7%

Died

6 2.0%

Euthanised

13 4.4%

Not known

153 52%

Problems reported at the same time

Behaviour change

96 33%

Lethargy

92 31%

Restlessness or agitation

75 25%

64 22%

54 18%

51 17%

48 16%

46 16%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Imidacloprid kills fleas (spot-on or collar). Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this combination include Advantage Multi. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Imidacloprid + Moxidectin cause vocalising in dogs?: 295 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vocalising with similar medicines

Vocalising after Spinosad (Comfortis) 586 reports · 1.0% of its reports
Vocalising after Lufenuron + Milbemycin Oxime (Sentinel) 180 reports · 0.7% of its reports
Vocalising after Nitenpyram (Capstar) 262 reports · 2.4% of its reports
Vocalising after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 45 reports · 0.5% of its reports
Vocalising after Fipronil + S-methoprene (Frontline Plus) 67 reports · 2.3% of its reports
Vocalising after Flumethrin + Imidacloprid (Seresto) 53 reports · 2.3% of its reports
Vocalising after Imidacloprid 46 reports · 2.4% of its reports
Vocalising after Fipronil 28 reports · 2.0% of its reports
Vocalising after Imidacloprid + Permethrin + Pyriproxyfen 29 reports · 3.9% of its reports
Vocalising after Cyphenothrin + Fipronil + S-methoprene 55 reports · 8.5% of its reports

All reported side effects of Imidacloprid + Moxidectin in dogs · Medicines most reported with vocalising