Kidney problems after Lufenuron + Milbemycin Oxime (Sentinel) in dogs

162 reports to the FDA describe kidney problems in dogs given Lufenuron + Milbemycin Oxime. That is 0.6% of all reports for this medicine, compared with 2.4% across reports for all dog medicines, so it is reported less often than average with this medicine.

162Reports

59%Marked serious

12%Recovered

30%Died or euthanised

20 daysTypical onset

How soon it started

Same day

19 32%

1–2 days

6 10%

3–7 days

1 1.7%

1–4 weeks

7 12%

Over a month

26 44%

How the animals did

Recovered

16 9.9%

Recovered with lasting effects

3 1.9%

Still unwell when reported

32 20%

Died

29 18%

Euthanised

20 12%

Not known

62 38%

Problems reported at the same time

72 44%

65 40%

62 38%

60 37%

49 30%

48 30%

33 20%

32 20%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this combination include Sentinel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime cause kidney problems in dogs?: 162 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 20 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Kidney problems with similar medicines

Kidney problems after Spinosad (Comfortis) 439 reports · 0.8% of its reports
Kidney problems after Imidacloprid + Moxidectin (Advantage Multi) 106 reports · 0.8% of its reports
Kidney problems after Nitenpyram (Capstar) 55 reports · 0.5% of its reports
Kidney problems after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 46 reports · 0.5% of its reports
Kidney problems after Fipronil + S-methoprene (Frontline Plus) 31 reports · 1.0% of its reports
Kidney problems after Flumethrin + Imidacloprid (Seresto) 27 reports · 1.2% of its reports
Kidney problems after Fipronil 30 reports · 2.1% of its reports
Kidney problems after Lufenuron 25 reports · 2.5% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime in dogs · Medicines most reported with kidney problems