Underdose after Lufenuron + Milbemycin Oxime (Sentinel) in dogs

The FDA has received 332 reports of underdose in dogs after Lufenuron + Milbemycin Oxime. That is 1.3% of all reports for this medicine, compared with 1.0% across reports for all dog medicines.

332Reports

23%Marked serious

17%Recovered

0.3%Died or euthanised

26 daysTypical onset

How soon it started

Same day

10 13%

1–2 days

2 2.5%

3–7 days

7 8.9%

1–4 weeks

27 34%

Over a month

33 42%

How the animals did

Recovered

56 17%

Recovered with lasting effects

1 0.3%

Still unwell when reported

58 17%

Euthanised

1 0.3%

Not known

216 65%

Problems reported at the same time

Didn't prevent heartworm

145 44%

Didn't stop worms

77 23%

Didn't work as expected

65 20%

37 11%

30 9.0%

25 7.5%

13 3.9%

13 3.9%

Age of the animals

Under 1 year

1–3 years

161

4–7 years

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this combination include Sentinel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime cause underdose in dogs?: 332 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 26 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Underdose with similar medicines

Underdose after Spinosad (Comfortis) 365 reports · 0.6% of its reports
Underdose after Imidacloprid + Moxidectin (Advantage Multi) 144 reports · 1.1% of its reports
Underdose after Nitenpyram (Capstar) 139 reports · 1.3% of its reports
Underdose after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 132 reports · 1.3% of its reports
Underdose after Fipronil + S-methoprene (Frontline Plus) 31 reports · 1.0% of its reports
Underdose after Imidacloprid 48 reports · 2.5% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime in dogs · Medicines most reported with underdose