Underdose after Imidacloprid + Moxidectin (Advantage Multi) in dogs

The FDA has received 144 reports of underdose in dogs after Imidacloprid + Moxidectin. That is 1.1% of all reports for this medicine, compared with 1.0% across reports for all dog medicines.

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How soon it started

How the animals did

Problems reported at the same time

Age of the animals

About this medicine

Imidacloprid kills fleas (spot-on or collar). Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this combination include Advantage Multi. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Imidacloprid + Moxidectin cause underdose in dogs?

144 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.

How soon after a dose was it reported?

In half of the reports with dates, it started within 10 days of the first dose.

What should I do?

Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Underdose with similar medicines

• Underdose after Spinosad (Comfortis) 365 reports · 0.6% of its reports
• Underdose after Lufenuron + Milbemycin Oxime (Sentinel) 332 reports · 1.3% of its reports
• Underdose after Nitenpyram (Capstar) 139 reports · 1.3% of its reports
• Underdose after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 132 reports · 1.3% of its reports
• Underdose after Fipronil + S-methoprene (Frontline Plus) 31 reports · 1.0% of its reports
• Underdose after Imidacloprid 48 reports · 2.5% of its reports

All reported side effects of Imidacloprid + Moxidectin in dogs · Medicines most reported with underdose