Underdose after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) in dogs

132 reports to the FDA describe underdose in dogs given Lufenuron + Milbemycin Oxime + Praziquantel. That is 1.3% of all reports for this medicine, compared with 1.0% across reports for all dog medicines.

132Reports

27%Marked serious

15%Recovered

0.0%Died or euthanised

24 daysTypical onset

How soon it started

Same day

8 15%

1–2 days

2 3.6%

3–7 days

6 11%

1–4 weeks

17 31%

Over a month

22 40%

How the animals did

Recovered

19 14%

Recovered with lasting effects

1 0.8%

Still unwell when reported

28 21%

Not known

84 64%

Problems reported at the same time

Didn't prevent heartworm

62 47%

Didn't work as expected

24 18%

22 17%

13 9.8%

10 7.6%

9 6.8%

6 4.5%

6 4.5%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.

Products with this combination include Sentinel Spectrum. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime + Praziquantel cause underdose in dogs?: 132 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 24 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Underdose with similar medicines

Underdose after Spinosad (Comfortis) 365 reports · 0.6% of its reports
Underdose after Lufenuron + Milbemycin Oxime (Sentinel) 332 reports · 1.3% of its reports
Underdose after Imidacloprid + Moxidectin (Advantage Multi) 144 reports · 1.1% of its reports
Underdose after Nitenpyram (Capstar) 139 reports · 1.3% of its reports
Underdose after Fipronil + S-methoprene (Frontline Plus) 31 reports · 1.0% of its reports
Underdose after Imidacloprid 48 reports · 2.5% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with underdose