Underdose after Fipronil + S-methoprene (Frontline Plus) in dogs
The FDA has received 31 reports of underdose in dogs after Fipronil + S-methoprene. That is 1.0% of all reports for this medicine, compared with 1.0% across reports for all dog medicines.
31Reports
39%Marked serious
32%Recovered
0.0%Died or euthanised
28 daysTypical onset
Sponsored
How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Fipronil kills fleas and ticks (spot-on).
Products with this combination include Frontline Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Questions owners ask
- Can Fipronil + S-methoprene cause underdose in dogs?
- 31 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within 28 days of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Underdose with similar medicines
- Underdose after Spinosad (Comfortis) 365 reports · 0.6% of its reports
- Underdose after Lufenuron + Milbemycin Oxime (Sentinel) 332 reports · 1.3% of its reports
- Underdose after Imidacloprid + Moxidectin (Advantage Multi) 144 reports · 1.1% of its reports
- Underdose after Nitenpyram (Capstar) 139 reports · 1.3% of its reports
- Underdose after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 132 reports · 1.3% of its reports
- Underdose after Imidacloprid 48 reports · 2.5% of its reports
All reported side effects of Fipronil + S-methoprene in dogs · Medicines most reported with underdose