Disorientation after Lufenuron + Milbemycin Oxime (Sentinel) in dogs

154 reports to the FDA describe disorientation in dogs given Lufenuron + Milbemycin Oxime. That is 0.6% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported less often than average with this medicine.

154Reports

44%Marked serious

36%Recovered

8.4%Died or euthanised

1 daysTypical onset

How soon it started

Same day

31 40%

1–2 days

16 21%

3–7 days

5 6.4%

1–4 weeks

6 7.7%

Over a month

20 26%

How the animals did

Recovered

54 35%

Recovered with lasting effects

1 0.6%

Still unwell when reported

26 17%

Died

6 3.9%

Euthanised

7 4.5%

Not known

60 39%

Problems reported at the same time

64 42%

44 29%

37 24%

32 21%

32 21%

30 19%

29 19%

18 12%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this combination include Sentinel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime cause disorientation in dogs?: 154 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Disorientation with similar medicines

Disorientation after Spinosad (Comfortis) 497 reports · 0.9% of its reports
Disorientation after Imidacloprid + Moxidectin (Advantage Multi) 182 reports · 1.4% of its reports
Disorientation after Nitenpyram (Capstar) 183 reports · 1.7% of its reports
Disorientation after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 67 reports · 0.7% of its reports
Disorientation after Fipronil + S-methoprene (Frontline Plus) 34 reports · 1.2% of its reports
Disorientation after Imidacloprid 23 reports · 1.2% of its reports
Disorientation after Fipronil 24 reports · 1.7% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime in dogs · Medicines most reported with disorientation