Seizures after Lufenuron + Milbemycin Oxime (Sentinel) in dogs

The FDA has received 937 reports of seizures in dogs after Lufenuron + Milbemycin Oxime. That is 3.6% of all reports for this medicine, compared with 4.4% across reports for all dog medicines.

937Reports

41%Marked serious

39%Recovered

7.6%Died or euthanised

1 daysTypical onset

How soon it started

Same day

121 32%

1–2 days

93 24%

3–7 days

42 11%

1–4 weeks

44 11%

Over a month

84 22%

How the animals did

Recovered

354 38%

Recovered with lasting effects

15 1.6%

Still unwell when reported

89 9.5%

Died

36 3.8%

Euthanised

35 3.7%

Not known

408 44%

Problems reported at the same time

106 11%

97 10%

74 7.9%

67 7.2%

61 6.5%

57 6.1%

51 5.4%

37 3.9%

Age of the animals

Under 1 year

1–3 years

275

4–7 years

322

8–11 years

180

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this combination include Sentinel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime cause seizures in dogs?: 937 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Seizures with similar medicines

Seizures after Spinosad (Comfortis) 2,116 reports · 3.7% of its reports
Seizures after Imidacloprid + Moxidectin (Advantage Multi) 520 reports · 4.0% of its reports
Seizures after Nitenpyram (Capstar) 331 reports · 3.1% of its reports
Seizures after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 279 reports · 2.8% of its reports
Seizures after Fipronil + S-methoprene (Frontline Plus) 214 reports · 7.2% of its reports
Seizures after Flumethrin + Imidacloprid (Seresto) 123 reports · 5.4% of its reports
Seizures after Imidacloprid 43 reports · 2.3% of its reports
Seizures after Fipronil 72 reports · 5.1% of its reports
Seizures after Lufenuron 65 reports · 6.4% of its reports
Seizures after Imidacloprid + Permethrin + Pyriproxyfen 34 reports · 4.6% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime in dogs · Medicines most reported with seizures