Seizures after Imidacloprid + Moxidectin (Advantage Multi) in dogs

520 reports to the FDA describe seizures in dogs given Imidacloprid + Moxidectin. That is 4.0% of all reports for this medicine, compared with 4.4% across reports for all dog medicines.

520Reports

83%Marked serious

48%Recovered

10%Died or euthanised

1 daysTypical onset

How soon it started

Same day

113 33%

1–2 days

103 30%

3–7 days

32 9.4%

1–4 weeks

49 14%

Over a month

44 13%

How the animals did

Recovered

246 47%

Recovered with lasting effects

1 0.2%

Still unwell when reported

27 5.2%

Died

29 5.6%

Euthanised

24 4.6%

Not known

193 37%

Problems reported at the same time

83 16%

64 12%

58 11%

56 11%

52 10%

42 8.1%

34 6.5%

34 6.5%

Age of the animals

Under 1 year

1–3 years

100

4–7 years

187

8–11 years

104

12+ years

About this medicine

Imidacloprid kills fleas (spot-on or collar). Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this combination include Advantage Multi. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Imidacloprid + Moxidectin cause seizures in dogs?: 520 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Seizures with similar medicines

Seizures after Spinosad (Comfortis) 2,116 reports · 3.7% of its reports
Seizures after Lufenuron + Milbemycin Oxime (Sentinel) 937 reports · 3.6% of its reports
Seizures after Nitenpyram (Capstar) 331 reports · 3.1% of its reports
Seizures after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 279 reports · 2.8% of its reports
Seizures after Fipronil + S-methoprene (Frontline Plus) 214 reports · 7.2% of its reports
Seizures after Flumethrin + Imidacloprid (Seresto) 123 reports · 5.4% of its reports
Seizures after Imidacloprid 43 reports · 2.3% of its reports
Seizures after Fipronil 72 reports · 5.1% of its reports
Seizures after Lufenuron 65 reports · 6.4% of its reports
Seizures after Imidacloprid + Permethrin + Pyriproxyfen 34 reports · 4.6% of its reports

All reported side effects of Imidacloprid + Moxidectin in dogs · Medicines most reported with seizures