Weakness after Lufenuron + Milbemycin Oxime (Sentinel) in dogs

The FDA has received 192 reports of weakness in dogs after Lufenuron + Milbemycin Oxime. That is 0.7% of all reports for this medicine, compared with 1.4% across reports for all dog medicines, so it is reported less often than average with this medicine.

192Reports

54%Marked serious

28%Recovered

18%Died or euthanised

1 daysTypical onset

How soon it started

Same day

28 31%

1–2 days

33 37%

3–7 days

4 4.4%

1–4 weeks

6 6.7%

Over a month

19 21%

How the animals did

Recovered

48 25%

Recovered with lasting effects

5 2.6%

Still unwell when reported

27 14%

Died

23 12%

Euthanised

11 5.7%

Not known

78 41%

Problems reported at the same time

86 45%

66 34%

60 31%

57 30%

35 18%

33 17%

30 16%

25 13%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this combination include Sentinel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime cause weakness in dogs?: 192 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Weakness with similar medicines

Weakness after Spinosad (Comfortis) 332 reports · 0.6% of its reports
Weakness after Imidacloprid + Moxidectin (Advantage Multi) 159 reports · 1.2% of its reports
Weakness after Nitenpyram (Capstar) 75 reports · 0.7% of its reports
Weakness after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 55 reports · 0.6% of its reports
Weakness after Fipronil + S-methoprene (Frontline Plus) 39 reports · 1.3% of its reports
Weakness after Flumethrin + Imidacloprid (Seresto) 28 reports · 1.2% of its reports
Weakness after Imidacloprid 21 reports · 1.1% of its reports
Weakness after Fipronil 27 reports · 1.9% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime in dogs · Medicines most reported with weakness