Weakness after Imidacloprid + Moxidectin (Advantage Multi) in dogs

159 reports to the FDA describe weakness in dogs given Imidacloprid + Moxidectin. That is 1.2% of all reports for this medicine, compared with 1.4% across reports for all dog medicines.

159Reports

77%Marked serious

33%Recovered

21%Died or euthanised

1 daysTypical onset

How soon it started

Same day

35 30%

1–2 days

42 36%

3–7 days

11 9.5%

1–4 weeks

21 18%

Over a month

7 6.0%

How the animals did

Recovered

48 30%

Recovered with lasting effects

5 3.1%

Still unwell when reported

10 6.3%

Died

13 8.2%

Euthanised

20 13%

Not known

63 40%

Problems reported at the same time

65 41%

53 33%

46 29%

41 26%

39 25%

33 21%

25 16%

21 13%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Imidacloprid kills fleas (spot-on or collar). Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this combination include Advantage Multi. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Imidacloprid + Moxidectin cause weakness in dogs?: 159 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Weakness with similar medicines

Weakness after Spinosad (Comfortis) 332 reports · 0.6% of its reports
Weakness after Lufenuron + Milbemycin Oxime (Sentinel) 192 reports · 0.7% of its reports
Weakness after Nitenpyram (Capstar) 75 reports · 0.7% of its reports
Weakness after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 55 reports · 0.6% of its reports
Weakness after Fipronil + S-methoprene (Frontline Plus) 39 reports · 1.3% of its reports
Weakness after Flumethrin + Imidacloprid (Seresto) 28 reports · 1.2% of its reports
Weakness after Imidacloprid 21 reports · 1.1% of its reports
Weakness after Fipronil 27 reports · 1.9% of its reports

All reported side effects of Imidacloprid + Moxidectin in dogs · Medicines most reported with weakness