Drug dose administration interval too long after Lufenuron + Milbemycin Oxime (Sentinel) in dogs

The FDA has received 200 reports of drug dose administration interval too long in dogs after Lufenuron + Milbemycin Oxime. That is 0.8% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

200Reports

19%Marked serious

10%Recovered

1.0%Died or euthanised

32 daysTypical onset

How soon it started

Same day

3 6.3%

1–2 days

2 4.2%

3–7 days

0 0.0%

1–4 weeks

3 6.3%

Over a month

40 83%

How the animals did

Recovered

18 9.0%

Recovered with lasting effects

2 1.0%

Still unwell when reported

27 14%

Died

1 0.5%

Euthanised

1 0.5%

Not known

151 76%

Problems reported at the same time

Didn't stop worms

79 40%

Didn't work as expected

69 35%

Didn't prevent heartworm

54 27%

20 10%

15 7.5%

10 5.0%

8 4.0%

7 3.5%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this combination include Sentinel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime cause drug dose administration interval too long in dogs?: 200 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 32 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Drug dose administration interval too long with similar medicines

Drug dose administration interval too long after Spinosad (Comfortis) 111 reports · 0.2% of its reports
Drug dose administration interval too long after Imidacloprid + Moxidectin (Advantage Multi) 70 reports · 0.5% of its reports
Drug dose administration interval too long after Nitenpyram (Capstar) 57 reports · 0.5% of its reports
Drug dose administration interval too long after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 86 reports · 0.9% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime in dogs · Medicines most reported with drug dose administration interval too long