Loose stool after Fipronil + S-methoprene (Frontline Plus) in dogs
The FDA has received 35 reports of loose stool in dogs after Fipronil + S-methoprene. That is 1.2% of all reports for this medicine, compared with 0.9% across reports for all dog medicines.
35Reports
54%Marked serious
40%Recovered
0.0%Died or euthanised
7 daysTypical onset
Sponsored
How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Fipronil kills fleas and ticks (spot-on).
Products with this combination include Frontline Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Questions owners ask
- Can Fipronil + S-methoprene cause loose stool in dogs?
- 35 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within 7 days of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Loose stool with similar medicines
- Loose stool after Spinosad (Comfortis) 236 reports · 0.4% of its reports
- Loose stool after Lufenuron + Milbemycin Oxime (Sentinel) 315 reports · 1.2% of its reports
- Loose stool after Imidacloprid + Moxidectin (Advantage Multi) 161 reports · 1.2% of its reports
- Loose stool after Nitenpyram (Capstar) 89 reports · 0.8% of its reports
- Loose stool after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 116 reports · 1.2% of its reports
- Loose stool after Fipronil 21 reports · 1.5% of its reports
All reported side effects of Fipronil + S-methoprene in dogs · Medicines most reported with loose stool