Cough after Lufenuron + Milbemycin Oxime (Sentinel) in dogs

166 reports to the FDA describe cough in dogs given Lufenuron + Milbemycin Oxime. That is 0.6% of all reports for this medicine, compared with 0.8% across reports for all dog medicines.

166Reports
38%Marked serious
22%Recovered
11%Died or euthanised
25 daysTypical onset
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How soon it started

Same day
11 19%
1–2 days
8 14%
3–7 days
5 8.8%
1–4 weeks
6 11%
Over a month
27 47%

How the animals did

Recovered
33 20%
Recovered with lasting effects
3 1.8%
Still unwell when reported
16 9.6%
Died
15 9.0%
Euthanised
3 1.8%
Not known
96 58%

Problems reported at the same time

Age of the animals

Under 1 year
18
1–3 years
57
4–7 years
30
8–11 years
33
12+ years
26

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this combination include Sentinel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime cause cough in dogs?
166 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 25 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Cough with similar medicines

All reported side effects of Lufenuron + Milbemycin Oxime in dogs · Medicines most reported with cough