Cough after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) in dogs

The FDA has received 48 reports of cough in dogs after Lufenuron + Milbemycin Oxime + Praziquantel. That is 0.5% of all reports for this medicine, compared with 0.8% across reports for all dog medicines, so it is reported less often than average with this medicine.

48Reports

56%Marked serious

19%Recovered

2.1%Died or euthanised

7 daysTypical onset

How soon it started

Same day

8 30%

1–2 days

3 11%

3–7 days

3 11%

1–4 weeks

3 11%

Over a month

10 37%

How the animals did

Recovered

9 19%

Still unwell when reported

12 25%

Euthanised

1 2.1%

Not known

26 54%

Problems reported at the same time

Didn't prevent heartworm

19 40%

5 10%

5 10%

5 10%

4 8.3%

3 6.3%

3 6.3%

3 6.3%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.

Products with this combination include Sentinel Spectrum. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime + Praziquantel cause cough in dogs?: 48 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 7 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Cough with similar medicines

Cough after Spinosad (Comfortis) 299 reports · 0.5% of its reports
Cough after Lufenuron + Milbemycin Oxime (Sentinel) 166 reports · 0.6% of its reports
Cough after Imidacloprid + Moxidectin (Advantage Multi) 222 reports · 1.7% of its reports
Cough after Nitenpyram (Capstar) 46 reports · 0.4% of its reports
Cough after Fipronil + S-methoprene (Frontline Plus) 22 reports · 0.7% of its reports
Cough after Flumethrin + Imidacloprid (Seresto) 24 reports · 1.1% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with cough