Abnormal radiograph finding after Lufenuron + Milbemycin Oxime (Sentinel) in dogs

179 reports to the FDA describe abnormal radiograph finding in dogs given Lufenuron + Milbemycin Oxime. That is 0.7% of all reports for this medicine, compared with 0.9% across reports for all dog medicines.

179Reports

56%Marked serious

13%Recovered

22%Died or euthanised

20 daysTypical onset

How soon it started

Same day

8 13%

1–2 days

10 16%

3–7 days

5 7.8%

1–4 weeks

12 19%

Over a month

29 45%

How the animals did

Recovered

20 11%

Recovered with lasting effects

3 1.7%

Still unwell when reported

28 16%

Died

26 15%

Euthanised

13 7.3%

Not known

89 50%

Problems reported at the same time

85 47%

74 41%

67 37%

52 29%

Didn't prevent heartworm

49 27%

Liver problems

44 25%

Death

40 22%

Cardiac enlargement

29 16%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this combination include Sentinel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime cause abnormal radiograph finding in dogs?: 179 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 20 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Abnormal radiograph finding with similar medicines

Abnormal radiograph finding after Spinosad (Comfortis) 215 reports · 0.4% of its reports
Abnormal radiograph finding after Imidacloprid + Moxidectin (Advantage Multi) 89 reports · 0.7% of its reports
Abnormal radiograph finding after Nitenpyram (Capstar) 41 reports · 0.4% of its reports
Abnormal radiograph finding after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 40 reports · 0.4% of its reports
Abnormal radiograph finding after Fipronil 24 reports · 1.7% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime in dogs · Medicines most reported with abnormal radiograph finding