Abnormal radiograph finding after Imidacloprid + Moxidectin (Advantage Multi) in dogs

89 reports to the FDA describe abnormal radiograph finding in dogs given Imidacloprid + Moxidectin. That is 0.7% of all reports for this medicine, compared with 0.9% across reports for all dog medicines.

89Reports

83%Marked serious

17%Recovered

20%Died or euthanised

14 daysTypical onset

How soon it started

Same day

5 9.3%

1–2 days

9 17%

3–7 days

9 17%

1–4 weeks

18 33%

Over a month

13 24%

How the animals did

Recovered

15 17%

Still unwell when reported

6 6.7%

Died

10 11%

Euthanised

8 9.0%

Not known

50 56%

Problems reported at the same time

31 35%

28 31%

26 29%

21 24%

21 24%

19 21%

19 21%

Didn't prevent heartworm

18 20%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Imidacloprid kills fleas (spot-on or collar). Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this combination include Advantage Multi. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Imidacloprid + Moxidectin cause abnormal radiograph finding in dogs?: 89 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 14 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Abnormal radiograph finding with similar medicines

Abnormal radiograph finding after Spinosad (Comfortis) 215 reports · 0.4% of its reports
Abnormal radiograph finding after Lufenuron + Milbemycin Oxime (Sentinel) 179 reports · 0.7% of its reports
Abnormal radiograph finding after Nitenpyram (Capstar) 41 reports · 0.4% of its reports
Abnormal radiograph finding after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 40 reports · 0.4% of its reports
Abnormal radiograph finding after Fipronil 24 reports · 1.7% of its reports

All reported side effects of Imidacloprid + Moxidectin in dogs · Medicines most reported with abnormal radiograph finding