Overdose after Imidacloprid + Moxidectin (Advantage Multi) in dogs

The FDA has received 201 reports of overdose in dogs after Imidacloprid + Moxidectin. That is 1.5% of all reports for this medicine, compared with 1.3% across reports for all dog medicines.

201Reports
59%Marked serious
27%Recovered
2.5%Died or euthanised
6 daysTypical onset
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How soon it started

Same day
28 26%
1–2 days
20 19%
3–7 days
10 9.3%
1–4 weeks
26 24%
Over a month
24 22%

How the animals did

Recovered
53 26%
Recovered with lasting effects
1 0.5%
Still unwell when reported
20 10.0%
Died
4 2.0%
Euthanised
1 0.5%
Not known
122 61%

Problems reported at the same time

Age of the animals

Under 1 year
31
1–3 years
66
4–7 years
51
8–11 years
32
12+ years
15

About this medicine

Imidacloprid kills fleas (spot-on or collar). Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this combination include Advantage Multi. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Imidacloprid + Moxidectin cause overdose in dogs?
201 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 6 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Overdose with similar medicines

All reported side effects of Imidacloprid + Moxidectin in dogs · Medicines most reported with overdose