Drug dose administration interval too short after Imidacloprid + Moxidectin (Advantage Multi) in dogs

146 reports to the FDA describe drug dose administration interval too short in dogs given Imidacloprid + Moxidectin. That is 1.1% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

146Reports

51%Marked serious

26%Recovered

1.4%Died or euthanised

9 daysTypical onset

How soon it started

Same day

9 11%

1–2 days

11 14%

3–7 days

17 22%

1–4 weeks

25 32%

Over a month

17 22%

How the animals did

Recovered

38 26%

Still unwell when reported

4 2.7%

Died

1 0.7%

Euthanised

1 0.7%

Not known

102 70%

Problems reported at the same time

Didn't stop fleas

56 38%

Itching

35 24%

Didn't work as expected

21 14%

Overdose

19 13%

Didn't prevent heartworm

15 10%

Didn't stop worms

14 9.6%

Vomiting

11 7.5%

Lethargy

10 6.8%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Imidacloprid kills fleas (spot-on or collar). Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this combination include Advantage Multi. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Imidacloprid + Moxidectin cause drug dose administration interval too short in dogs?: 146 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 9 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Drug dose administration interval too short with similar medicines

Drug dose administration interval too short after Spinosad (Comfortis) 230 reports · 0.4% of its reports
Drug dose administration interval too short after Lufenuron + Milbemycin Oxime (Sentinel) 46 reports · 0.2% of its reports
Drug dose administration interval too short after Nitenpyram (Capstar) 72 reports · 0.7% of its reports
Drug dose administration interval too short after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 32 reports · 0.3% of its reports

All reported side effects of Imidacloprid + Moxidectin in dogs · Medicines most reported with drug dose administration interval too short