Drug dose administration interval too short after Spinosad (Comfortis) in dogs

230 reports to the FDA describe drug dose administration interval too short in dogs given Spinosad. That is 0.4% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

230Reports

11%Marked serious

25%Recovered

1.7%Died or euthanised

24 daysTypical onset

How soon it started

Same day

18 16%

1–2 days

1 0.9%

3–7 days

6 5.4%

1–4 weeks

38 34%

Over a month

48 43%

How the animals did

Recovered

31 13%

Recovered with lasting effects

26 11%

Still unwell when reported

4 1.7%

Died

3 1.3%

Euthanised

1 0.4%

Not known

165 72%

Problems reported at the same time

211 92%

38 17%

36 16%

31 13%

14 6.1%

12 5.2%

Didn't work as expected

11 4.8%

Skin rash or irritation

10 4.3%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Spinosad kills fleas; monthly chewable.

Products with this ingredient include Comfortis. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Spinosad cause drug dose administration interval too short in dogs?: 230 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 24 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Drug dose administration interval too short with similar medicines

Drug dose administration interval too short after Lufenuron + Milbemycin Oxime (Sentinel) 46 reports · 0.2% of its reports
Drug dose administration interval too short after Imidacloprid + Moxidectin (Advantage Multi) 146 reports · 1.1% of its reports
Drug dose administration interval too short after Nitenpyram (Capstar) 72 reports · 0.7% of its reports
Drug dose administration interval too short after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 32 reports · 0.3% of its reports

All reported side effects of Spinosad in dogs · Medicines most reported with drug dose administration interval too short