Drug dose administration interval too short after Lufenuron + Milbemycin Oxime (Sentinel) in dogs

The FDA has received 46 reports of drug dose administration interval too short in dogs after Lufenuron + Milbemycin Oxime. That is 0.2% of all reports for this medicine, compared with 0.2% across reports for all dog medicines.

46Reports

35%Marked serious

20%Recovered

0.0%Died or euthanised

7 daysTypical onset

How soon it started

Same day

4 15%

1–2 days

4 15%

3–7 days

6 23%

1–4 weeks

9 35%

Over a month

3 12%

How the animals did

Recovered

8 17%

Recovered with lasting effects

1 2.2%

Still unwell when reported

6 13%

Not known

31 67%

Problems reported at the same time

Didn't work as expected

13 28%

11 24%

11 24%

9 20%

9 20%

7 15%

6 13%

5 11%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this combination include Sentinel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime cause drug dose administration interval too short in dogs?: 46 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 7 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Drug dose administration interval too short with similar medicines

Drug dose administration interval too short after Spinosad (Comfortis) 230 reports · 0.4% of its reports
Drug dose administration interval too short after Imidacloprid + Moxidectin (Advantage Multi) 146 reports · 1.1% of its reports
Drug dose administration interval too short after Nitenpyram (Capstar) 72 reports · 0.7% of its reports
Drug dose administration interval too short after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 32 reports · 0.3% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime in dogs · Medicines most reported with drug dose administration interval too short