Clomipramine (Clomicalm) side effects in dogs

1,512 reports sent to the FDA between 1999 and 2026 involve Clomipramine in dogs. The most reported problems were lethargy, vomiting, liver problems. 13% were marked serious, and where it was recorded, signs eased after stopping the medicine in 29% of cases.

1,512Reports
13%Marked serious
84%Only medicine involved
11%Recovered
4.2%Died or euthanised
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About this medicine

Clomipramine treats separation anxiety.

Products with this ingredient include Clomicalm. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Most reported side effects

Share = percentage of this medicine's reports that mention the problem. One report can list several problems.

Reports that it didn't work

Some reports are about the medicine not working (for example a dog still getting fleas or heartworm), not about a side effect.

Didn't prevent heartworm
5 0.3%
Didn't stop fleas
2 0.1%
Didn't stop worms
1 0.1%

How soon problems started

Same day
72 23%
1–2 days
26 8.2%
3–7 days
33 10%
1–4 weeks
47 15%
Over a month
139 44%

Time from the first dose to the first sign, where both dates were reported (317 reports).

How the animals did

Recovered
147 9.7%
Recovered with lasting effects
13 0.9%
Still unwell when reported
130 8.6%
Died
57 3.8%
Euthanised
6 0.4%
Not known
1,159 77%

Breeds named most often

Popular breeds appear more often because there are more of them.

Other behaviour or anxiety medicines for dogs