Diarrhea after Clomipramine (Clomicalm) in dogs

The FDA has received 138 reports of diarrhea in dogs after Clomipramine. That is 9.1% of all reports for this medicine, compared with 8.4% across reports for all dog medicines.

138Reports
16%Marked serious
12%Recovered
5.1%Died or euthanised
9 daysTypical onset
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How soon it started

Same day
9 21%
1–2 days
6 14%
3–7 days
6 14%
1–4 weeks
4 9.5%
Over a month
17 40%

How the animals did

Recovered
15 11%
Recovered with lasting effects
1 0.7%
Still unwell when reported
17 12%
Died
6 4.3%
Euthanised
1 0.7%
Not known
98 71%

Problems reported at the same time

Age of the animals

Under 1 year
7
1–3 years
39
4–7 years
40
8–11 years
29
12+ years
17

About this medicine

Clomipramine treats separation anxiety.

Products with this ingredient include Clomicalm. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Clomipramine cause diarrhea in dogs?
138 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 9 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Diarrhea with similar medicines

All reported side effects of Clomipramine in dogs · Medicines most reported with diarrhea