Restlessness or agitation after Clomipramine (Clomicalm) in dogs

The FDA has received 79 reports of restlessness or agitation in dogs after Clomipramine. That is 5.2% of all reports for this medicine, compared with 1.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

79Reports
5.1%Marked serious
11%Recovered
1.3%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
7 44%
1–2 days
3 19%
3–7 days
1 6.3%
1–4 weeks
3 19%
Over a month
2 13%

How the animals did

Recovered
8 10%
Recovered with lasting effects
1 1.3%
Still unwell when reported
6 7.6%
Died
1 1.3%
Not known
63 80%

Problems reported at the same time

Age of the animals

Under 1 year
4
1–3 years
20
4–7 years
28
8–11 years
15
12+ years
10

About this medicine

Clomipramine treats separation anxiety.

Products with this ingredient include Clomicalm. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Clomipramine cause restlessness or agitation in dogs?
79 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Restlessness or agitation with similar medicines

All reported side effects of Clomipramine in dogs · Medicines most reported with restlessness or agitation