Restlessness or agitation after Trazodone in dogs

86 reports to the FDA describe restlessness or agitation in dogs given Trazodone. That is 3.4% of all reports for this medicine, compared with 1.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

86Reports

64%Marked serious

19%Recovered

12%Died or euthanised

5 daysTypical onset

How soon it started

Same day

18 27%

1–2 days

12 18%

3–7 days

6 9.1%

1–4 weeks

10 15%

Over a month

20 30%

How the animals did

Recovered

16 19%

Still unwell when reported

36 42%

Died

4 4.7%

Euthanised

6 7.0%

Not known

24 28%

Problems reported at the same time

32 37%

25 29%

18 21%

18 21%

16 19%

14 16%

13 15%

12 14%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Trazodone reduces anxiety and stress.

Questions owners ask

Can Trazodone cause restlessness or agitation in dogs?: 86 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 5 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Restlessness or agitation with similar medicines

Restlessness or agitation after Gabapentin 272 reports · 3.0% of its reports
Restlessness or agitation after Selegiline (Anipryl) 394 reports · 9.6% of its reports
Restlessness or agitation after Fluoxetine 117 reports · 4.5% of its reports
Restlessness or agitation after Clomipramine (Clomicalm) 79 reports · 5.2% of its reports

All reported side effects of Trazodone in dogs · Medicines most reported with restlessness or agitation