Liver problems after Trazodone in dogs

The FDA has received 286 reports of liver problems in dogs after Trazodone. That is 11% of all reports for this medicine, compared with 4.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

286Reports

70%Marked serious

7.7%Recovered

21%Died or euthanised

20 daysTypical onset

How soon it started

Same day

30 14%

1–2 days

27 13%

3–7 days

25 12%

1–4 weeks

47 22%

Over a month

85 40%

How the animals did

Recovered

22 7.7%

Still unwell when reported

135 47%

Died

18 6.3%

Euthanised

43 15%

Not known

68 24%

Problems reported at the same time

120 42%

105 37%

89 31%

76 27%

74 26%

58 20%

Abnormal ultrasound finding

47 16%

Breathing problems

44 15%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Trazodone reduces anxiety and stress.

Questions owners ask

Can Trazodone cause liver problems in dogs?: 286 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 20 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

Liver problems after Gabapentin 1,228 reports · 14% of its reports
Liver problems after Selegiline (Anipryl) 325 reports · 7.9% of its reports
Liver problems after Fluoxetine 136 reports · 5.3% of its reports
Liver problems after Clomipramine (Clomicalm) 271 reports · 18% of its reports

All reported side effects of Trazodone in dogs · Medicines most reported with liver problems