Liver problems after Selegiline (Anipryl) in dogs

325 reports to the FDA describe liver problems in dogs given Selegiline. That is 7.9% of all reports for this medicine, compared with 4.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

325Reports
2.5%Marked serious
0.3%Recovered
9.5%Died or euthanised
44 daysTypical onset
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How soon it started

Same day
1 6.7%
1–2 days
0 0.0%
3–7 days
2 13%
1–4 weeks
4 27%
Over a month
8 53%

How the animals did

Recovered
1 0.3%
Still unwell when reported
12 3.7%
Died
30 9.2%
Euthanised
1 0.3%
Not known
281 86%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
4
4–7 years
12
8–11 years
93
12+ years
209

About this medicine

Selegiline treats canine cognitive dysfunction.

Products with this ingredient include Anipryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Selegiline cause liver problems in dogs?
325 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 44 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

All reported side effects of Selegiline in dogs · Medicines most reported with liver problems