Liver problems after Fluoxetine in dogs

136 reports to the FDA describe liver problems in dogs given Fluoxetine. That is 5.3% of all reports for this medicine, compared with 4.6% across reports for all dog medicines.

136Reports

46%Marked serious

14%Recovered

10%Died or euthanised

37 daysTypical onset

How soon it started

Same day

9 11%

1–2 days

5 6.3%

3–7 days

5 6.3%

1–4 weeks

17 22%

Over a month

43 54%

How the animals did

Recovered

11 8.1%

Recovered with lasting effects

8 5.9%

Still unwell when reported

49 36%

Died

4 2.9%

Euthanised

10 7.4%

Not known

54 40%

Problems reported at the same time

38 28%

37 27%

27 20%

27 20%

16 12%

15 11%

Didn't work as expected

15 11%

Blood problems

15 11%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Fluoxetine treats anxiety and behaviour problems.

Questions owners ask

Can Fluoxetine cause liver problems in dogs?: 136 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 37 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

Liver problems after Gabapentin 1,228 reports · 14% of its reports
Liver problems after Selegiline (Anipryl) 325 reports · 7.9% of its reports
Liver problems after Trazodone 286 reports · 11% of its reports
Liver problems after Clomipramine (Clomicalm) 271 reports · 18% of its reports

All reported side effects of Fluoxetine in dogs · Medicines most reported with liver problems