Didn't work as expected after Fluoxetine in dogs

489 reports to the FDA describe didn't work as expected in dogs given Fluoxetine. That is 19% of all reports for this medicine, compared with 13% across reports for all dog medicines.

489Reports

14%Marked serious

12%Recovered

1.8%Died or euthanised

39 daysTypical onset

How soon it started

Same day

28 15%

1–2 days

12 6.3%

3–7 days

11 5.8%

1–4 weeks

34 18%

Over a month

106 55%

How the animals did

Recovered

37 7.6%

Recovered with lasting effects

20 4.1%

Still unwell when reported

54 11%

Died

5 1.0%

Euthanised

4 0.8%

Not known

369 75%

Problems reported at the same time

40 8.2%

36 7.4%

26 5.3%

23 4.7%

23 4.7%

22 4.5%

20 4.1%

18 3.7%

Age of the animals

Under 1 year

1–3 years

115

4–7 years

142

8–11 years

119

12+ years

About this medicine

Fluoxetine treats anxiety and behaviour problems.

Questions owners ask

Can Fluoxetine cause didn't work as expected in dogs?: 489 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 39 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Didn't work as expected with similar medicines

Didn't work as expected after Gabapentin 1,277 reports · 14% of its reports
Didn't work as expected after Selegiline (Anipryl) 1,228 reports · 30% of its reports
Didn't work as expected after Trazodone 290 reports · 11% of its reports
Didn't work as expected after Clomipramine (Clomicalm) 187 reports · 12% of its reports

All reported side effects of Fluoxetine in dogs · Medicines most reported with didn't work as expected