Anxiety after Fluoxetine in dogs

The FDA has received 92 reports of anxiety in dogs after Fluoxetine. That is 3.6% of all reports for this medicine, compared with 0.5% across reports for all dog medicines, so it is reported unusually often with this medicine.

92Reports

36%Marked serious

35%Recovered

3.3%Died or euthanised

37 daysTypical onset

How soon it started

Same day

14 23%

1–2 days

6 9.8%

3–7 days

7 11%

1–4 weeks

3 4.9%

Over a month

31 51%

How the animals did

Recovered

22 24%

Recovered with lasting effects

10 11%

Still unwell when reported

29 32%

Euthanised

3 3.3%

Not known

28 30%

Problems reported at the same time

Behaviour change

28 30%

Didn't work as expected

23 25%

22 24%

21 23%

16 17%

13 14%

13 14%

10 11%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Fluoxetine treats anxiety and behaviour problems.

Questions owners ask

Can Fluoxetine cause anxiety in dogs?: 92 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 37 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Anxiety with similar medicines

Anxiety after Gabapentin 204 reports · 2.3% of its reports
Anxiety after Trazodone 101 reports · 4.0% of its reports
Anxiety after Clomipramine (Clomicalm) 28 reports · 1.9% of its reports

All reported side effects of Fluoxetine in dogs · Medicines most reported with anxiety