Didn't work as expected after Clomipramine (Clomicalm) in dogs

The FDA has received 187 reports of didn't work as expected in dogs after Clomipramine. That is 12% of all reports for this medicine, compared with 13% across reports for all dog medicines.

187Reports
19%Marked serious
11%Recovered
2.7%Died or euthanised
31 daysTypical onset
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How soon it started

Same day
10 12%
1–2 days
3 3.6%
3–7 days
12 14%
1–4 weeks
17 20%
Over a month
42 50%

How the animals did

Recovered
15 8.0%
Recovered with lasting effects
6 3.2%
Still unwell when reported
15 8.0%
Died
3 1.6%
Euthanised
2 1.1%
Not known
146 78%

Problems reported at the same time

Behaviour change
22 12%
Underdose
17 9.1%
Vomiting
12 6.4%
Lethargy
11 5.9%
Overdose
10 5.3%
Loss of appetite
9 4.8%
Liver problems
8 4.3%
Death
5 2.7%

Age of the animals

Under 1 year
6
1–3 years
51
4–7 years
55
8–11 years
44
12+ years
18

About this medicine

Clomipramine treats separation anxiety.

Products with this ingredient include Clomicalm. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Clomipramine cause didn't work as expected in dogs?
187 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 31 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Didn't work as expected with similar medicines

All reported side effects of Clomipramine in dogs · Medicines most reported with didn't work as expected