Restlessness or agitation after Selegiline (Anipryl) in dogs

The FDA has received 394 reports of restlessness or agitation in dogs after Selegiline. That is 9.6% of all reports for this medicine, compared with 1.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

394Reports
1.5%Marked serious
0.8%Recovered
7.1%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
14 48%
1–2 days
2 6.9%
3–7 days
1 3.4%
1–4 weeks
4 14%
Over a month
8 28%

How the animals did

Recovered
3 0.8%
Still unwell when reported
15 3.8%
Died
28 7.1%
Not known
348 88%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
4
4–7 years
4
8–11 years
74
12+ years
295

About this medicine

Selegiline treats canine cognitive dysfunction.

Products with this ingredient include Anipryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Selegiline cause restlessness or agitation in dogs?
394 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Restlessness or agitation with similar medicines

All reported side effects of Selegiline in dogs · Medicines most reported with restlessness or agitation