Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) side effects in dogs
3,081 reports sent to the FDA between 2023 and 2026 involve Lotilaner + Moxidectin + Praziquantel + Pyrantel in dogs. The most reported problems were vomiting, diarrhea, lethargy. 11% were marked serious, and where it was recorded, signs eased after stopping the medicine in 100% of cases.
About this medicine
Lotilaner kills fleas and ticks; monthly chewable. Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs). Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.
Products with this combination include Credelio Quattro. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.
Most reported side effects
Share = percentage of this medicine's reports that mention the problem. One report can list several problems.
Reports that it didn't work
Some reports are about the medicine not working (for example a dog still getting fleas or heartworm), not about a side effect.
How soon problems started
Time from the first dose to the first sign, where both dates were reported (2,752 reports).
How the animals did
Breeds named most often
Popular breeds appear more often because there are more of them.
- Labrador Retriever 188 reports
- Golden Retriever 148 reports
- German Shepherd Dog 86 reports
- Australian Shepherd Dog 84 reports
- Shih Tzu 75 reports
- Dachshund 56 reports
- Chihuahua 53 reports
- Yorkshire Terrier 47 reports
- Dog (other) 38 reports
- French Bulldog 36 reports