Didn't prevent heartworm after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) in dogs

126 reports to the FDA describe didn't prevent heartworm in dogs given Lotilaner + Moxidectin + Praziquantel + Pyrantel. That is 4.1% of all reports for this medicine, compared with 13% across reports for all dog medicines, so it is reported less often than average with this medicine.

126Reports

9.5%Marked serious

0.0%Recovered

1.6%Died or euthanised

203 daysTypical onset

How soon it started

Same day

2 2.9%

1–2 days

0 0.0%

3–7 days

1 1.4%

1–4 weeks

4 5.8%

Over a month

62 90%

How the animals did

Still unwell when reported

11 8.7%

Died

1 0.8%

Euthanised

1 0.8%

Not known

113 90%

Problems reported at the same time

Didn't work as expected

5 4.0%

Vomiting

4 3.2%

Weight gain

3 2.4%

Neutrophilia

3 2.4%

Weight loss

3 2.4%

Medication error

2 1.6%

Leucocytosis

2 1.6%

Excessive urination

2 1.6%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lotilaner kills fleas and ticks; monthly chewable. Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs). Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Products with this combination include Credelio Quattro. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Lotilaner + Moxidectin + Praziquantel + Pyrantel cause didn't prevent heartworm in dogs?: 126 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 203 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Didn't prevent heartworm with similar medicines

Didn't prevent heartworm after Fluralaner (Bravecto) 638 reports · 0.9% of its reports
Didn't prevent heartworm after Afoxolaner (NexGard) 831 reports · 1.5% of its reports
Didn't prevent heartworm after Sarolaner (Simparica) 287 reports · 1.7% of its reports
Didn't prevent heartworm after Lotilaner (Credelio) 487 reports · 4.9% of its reports
Didn't prevent heartworm after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 1,168 reports · 13% of its reports

All reported side effects of Lotilaner + Moxidectin + Praziquantel + Pyrantel in dogs · Medicines most reported with didn't prevent heartworm