Vomiting after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) in dogs

1,058 reports to the FDA describe vomiting in dogs given Lotilaner + Moxidectin + Praziquantel + Pyrantel. That is 34% of all reports for this medicine, compared with 28% across reports for all dog medicines.

1,058Reports

7.8%Marked serious

63%Recovered

2.1%Died or euthanised

Same dayTypical onset

How soon it started

Same day

639 64%

1–2 days

104 10%

3–7 days

32 3.2%

1–4 weeks

55 5.5%

Over a month

171 17%

How the animals did

Recovered

668 63%

Still unwell when reported

172 16%

Died

14 1.3%

Euthanised

8 0.8%

Not known

196 19%

Problems reported at the same time

296 28%

181 17%

142 13%

43 4.1%

41 3.9%

34 3.2%

30 2.8%

28 2.6%

Age of the animals

Under 1 year

237

1–3 years

294

4–7 years

258

8–11 years

137

12+ years

About this medicine

Lotilaner kills fleas and ticks; monthly chewable. Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs). Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Products with this combination include Credelio Quattro. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Lotilaner + Moxidectin + Praziquantel + Pyrantel cause vomiting in dogs?: 1,058 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vomiting with similar medicines

Vomiting after Fluralaner (Bravecto) 26,091 reports · 38% of its reports
Vomiting after Afoxolaner (NexGard) 15,643 reports · 27% of its reports
Vomiting after Sarolaner (Simparica) 4,059 reports · 24% of its reports
Vomiting after Lotilaner (Credelio) 3,043 reports · 31% of its reports
Vomiting after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 1,792 reports · 19% of its reports

All reported side effects of Lotilaner + Moxidectin + Praziquantel + Pyrantel in dogs · Medicines most reported with vomiting