Diarrhea after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) in dogs

680 reports to the FDA describe diarrhea in dogs given Lotilaner + Moxidectin + Praziquantel + Pyrantel. That is 22% of all reports for this medicine, compared with 8.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

680Reports

9.6%Marked serious

49%Recovered

2.5%Died or euthanised

1 daysTypical onset

How soon it started

Same day

309 48%

1–2 days

145 23%

3–7 days

27 4.2%

1–4 weeks

31 4.8%

Over a month

132 20%

How the animals did

Recovered

335 49%

Still unwell when reported

179 26%

Died

11 1.6%

Euthanised

6 0.9%

Not known

149 22%

Problems reported at the same time

296 44%

141 21%

106 16%

27 4.0%

24 3.5%

21 3.1%

21 3.1%

Didn't work as expected

18 2.6%

Age of the animals

Under 1 year

142

1–3 years

190

4–7 years

177

8–11 years

12+ years

About this medicine

Lotilaner kills fleas and ticks; monthly chewable. Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs). Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Products with this combination include Credelio Quattro. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Lotilaner + Moxidectin + Praziquantel + Pyrantel cause diarrhea in dogs?: 680 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Diarrhea with similar medicines

Diarrhea after Fluralaner (Bravecto) 5,046 reports · 7.3% of its reports
Diarrhea after Afoxolaner (NexGard) 6,014 reports · 11% of its reports
Diarrhea after Sarolaner (Simparica) 1,487 reports · 8.9% of its reports
Diarrhea after Lotilaner (Credelio) 1,243 reports · 12% of its reports
Diarrhea after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 938 reports · 10% of its reports

All reported side effects of Lotilaner + Moxidectin + Praziquantel + Pyrantel in dogs · Medicines most reported with diarrhea