Behaviour change after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) in dogs
199 reports to the FDA describe behaviour change in dogs given Lotilaner + Moxidectin + Praziquantel + Pyrantel. That is 6.5% of all reports for this medicine, compared with 2.5% across reports for all dog medicines, so it is reported unusually often with this medicine.
How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Lotilaner kills fleas and ticks; monthly chewable. Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs). Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.
Products with this combination include Credelio Quattro. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.
Questions owners ask
- Can Lotilaner + Moxidectin + Praziquantel + Pyrantel cause behaviour change in dogs?
- 199 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within 1 day of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Behaviour change with similar medicines
- Behaviour change after Fluralaner (Bravecto) 1,712 reports · 2.5% of its reports
- Behaviour change after Afoxolaner (NexGard) 1,819 reports · 3.2% of its reports
- Behaviour change after Sarolaner (Simparica) 718 reports · 4.3% of its reports
- Behaviour change after Lotilaner (Credelio) 488 reports · 4.9% of its reports
- Behaviour change after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 172 reports · 1.9% of its reports
All reported side effects of Lotilaner + Moxidectin + Praziquantel + Pyrantel in dogs · Medicines most reported with behaviour change