Vomiting after Sarolaner (Simparica) in dogs

4,059 reports to the FDA describe vomiting in dogs given Sarolaner. That is 24% of all reports for this medicine, compared with 28% across reports for all dog medicines.

4,059Reports

18%Marked serious

46%Recovered

3.1%Died or euthanised

Same dayTypical onset

How soon it started

Same day

2,620 69%

1–2 days

575 15%

3–7 days

185 4.9%

1–4 weeks

140 3.7%

Over a month

254 6.7%

How the animals did

Recovered

1,868 46%

Still unwell when reported

987 24%

Died

60 1.5%

Euthanised

67 1.7%

Not known

1,077 27%

Problems reported at the same time

818 20%

633 16%

597 15%

310 7.6%

222 5.5%

166 4.1%

135 3.3%

134 3.3%

Age of the animals

Under 1 year

476

1–3 years

1,308

4–7 years

977

8–11 years

642

12+ years

317

About this medicine

Sarolaner kills fleas, ticks and some mites; monthly.

Products with this ingredient include Simparica. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Sarolaner cause vomiting in dogs?: 4,059 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vomiting with similar medicines

Vomiting after Fluralaner (Bravecto) 26,091 reports · 38% of its reports
Vomiting after Afoxolaner (NexGard) 15,643 reports · 27% of its reports
Vomiting after Lotilaner (Credelio) 3,043 reports · 31% of its reports
Vomiting after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 1,792 reports · 19% of its reports
Vomiting after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) 1,058 reports · 34% of its reports

All reported side effects of Sarolaner in dogs · Medicines most reported with vomiting