Sarolaner (Simparica) side effects in dogs
16,661 reports sent to the FDA between 2016 and 2026 involve Sarolaner in dogs. The most reported problems were vomiting, seizures, tremors. 35% were marked serious, and where it was recorded, signs eased after stopping the medicine in 20% of cases.
About this medicine
Sarolaner kills fleas, ticks and some mites; monthly.
Products with this ingredient include Simparica. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.
Most reported side effects
Share = percentage of this medicine's reports that mention the problem. One report can list several problems.
Reports that it didn't work
Some reports are about the medicine not working (for example a dog still getting fleas or heartworm), not about a side effect.
How soon problems started
Time from the first dose to the first sign, where both dates were reported (13,488 reports).
How the animals did
Breeds named most often
Popular breeds appear more often because there are more of them.
- Labrador Retriever 1,136 reports
- Golden Retriever 658 reports
- Yorkshire Terrier 621 reports
- Chihuahua 523 reports
- German Shepherd Dog 446 reports
- Shih Tzu 438 reports
- Australian Shepherd Dog 328 reports
- Bull - American Pit Terrier 326 reports
- Siberian Husky 285 reports
- Beagle 270 reports