Restlessness or agitation after Sarolaner (Simparica) in dogs

291 reports to the FDA describe restlessness or agitation in dogs given Sarolaner. That is 1.7% of all reports for this medicine, compared with 1.6% across reports for all dog medicines.

291Reports

35%Marked serious

32%Recovered

3.8%Died or euthanised

Same dayTypical onset

How soon it started

Same day

160 59%

1–2 days

60 22%

3–7 days

11 4.0%

1–4 weeks

15 5.5%

Over a month

27 9.9%

How the animals did

Recovered

92 32%

Still unwell when reported

109 37%

Died

3 1.0%

Euthanised

8 2.7%

Not known

79 27%

Problems reported at the same time

82 28%

62 21%

59 20%

58 20%

48 16%

45 15%

41 14%

41 14%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Sarolaner kills fleas, ticks and some mites; monthly.

Products with this ingredient include Simparica. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Sarolaner cause restlessness or agitation in dogs?: 291 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Restlessness or agitation with similar medicines

Restlessness or agitation after Fluralaner (Bravecto) 624 reports · 0.9% of its reports
Restlessness or agitation after Afoxolaner (NexGard) 1,179 reports · 2.1% of its reports
Restlessness or agitation after Lotilaner (Credelio) 139 reports · 1.4% of its reports
Restlessness or agitation after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 93 reports · 1.0% of its reports
Restlessness or agitation after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) 33 reports · 1.1% of its reports

All reported side effects of Sarolaner in dogs · Medicines most reported with restlessness or agitation