Restlessness or agitation after Fluralaner (Bravecto) in dogs

624 reports to the FDA describe restlessness or agitation in dogs given Fluralaner. That is 0.9% of all reports for this medicine, compared with 1.6% across reports for all dog medicines, so it is reported less often than average with this medicine.

624Reports

70%Marked serious

36%Recovered

8.2%Died or euthanised

Same dayTypical onset

How soon it started

Same day

221 51%

1–2 days

86 20%

3–7 days

35 8.1%

1–4 weeks

27 6.2%

Over a month

64 15%

How the animals did

Recovered

216 35%

Recovered with lasting effects

9 1.4%

Still unwell when reported

263 42%

Died

15 2.4%

Euthanised

36 5.8%

Not known

85 14%

Problems reported at the same time

177 28%

160 26%

146 23%

137 22%

131 21%

127 20%

115 18%

88 14%

Age of the animals

Under 1 year

1–3 years

163

4–7 years

169

8–11 years

130

12+ years

105

About this medicine

Fluralaner kills fleas and ticks for up to 12 weeks (chewable or spot-on).

Products with this ingredient include Bravecto. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Fluralaner cause restlessness or agitation in dogs?: 624 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Restlessness or agitation with similar medicines

Restlessness or agitation after Afoxolaner (NexGard) 1,179 reports · 2.1% of its reports
Restlessness or agitation after Sarolaner (Simparica) 291 reports · 1.7% of its reports
Restlessness or agitation after Lotilaner (Credelio) 139 reports · 1.4% of its reports
Restlessness or agitation after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 93 reports · 1.0% of its reports
Restlessness or agitation after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) 33 reports · 1.1% of its reports

All reported side effects of Fluralaner in dogs · Medicines most reported with restlessness or agitation