Restlessness or agitation after Lotilaner (Credelio) in dogs

The FDA has received 139 reports of restlessness or agitation in dogs after Lotilaner. That is 1.4% of all reports for this medicine, compared with 1.6% across reports for all dog medicines.

139Reports

22%Marked serious

32%Recovered

2.9%Died or euthanised

1 daysTypical onset

How soon it started

Same day

60 47%

1–2 days

25 20%

3–7 days

8 6.3%

1–4 weeks

13 10%

Over a month

22 17%

How the animals did

Recovered

44 32%

Still unwell when reported

57 41%

Euthanised

4 2.9%

Not known

34 24%

Problems reported at the same time

38 27%

38 27%

27 19%

26 19%

26 19%

26 19%

19 14%

18 13%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lotilaner kills fleas and ticks; monthly chewable.

Products with this ingredient include Credelio. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Lotilaner cause restlessness or agitation in dogs?: 139 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Restlessness or agitation with similar medicines

Restlessness or agitation after Fluralaner (Bravecto) 624 reports · 0.9% of its reports
Restlessness or agitation after Afoxolaner (NexGard) 1,179 reports · 2.1% of its reports
Restlessness or agitation after Sarolaner (Simparica) 291 reports · 1.7% of its reports
Restlessness or agitation after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 93 reports · 1.0% of its reports
Restlessness or agitation after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) 33 reports · 1.1% of its reports

All reported side effects of Lotilaner in dogs · Medicines most reported with restlessness or agitation