Vocalising after Lotilaner (Credelio) in dogs

The FDA has received 142 reports of vocalising in dogs after Lotilaner. That is 1.4% of all reports for this medicine, compared with 1.2% across reports for all dog medicines.

142Reports

33%Marked serious

30%Recovered

9.9%Died or euthanised

1 daysTypical onset

How soon it started

Same day

49 39%

1–2 days

30 24%

3–7 days

7 5.6%

1–4 weeks

11 8.7%

Over a month

29 23%

How the animals did

Recovered

43 30%

Still unwell when reported

56 39%

Died

6 4.2%

Euthanised

8 5.6%

Not known

29 20%

Problems reported at the same time

43 30%

37 26%

35 25%

30 21%

26 18%

25 18%

23 16%

23 16%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lotilaner kills fleas and ticks; monthly chewable.

Products with this ingredient include Credelio. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Lotilaner cause vocalising in dogs?: 142 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vocalising with similar medicines

Vocalising after Fluralaner (Bravecto) 636 reports · 0.9% of its reports
Vocalising after Afoxolaner (NexGard) 793 reports · 1.4% of its reports
Vocalising after Sarolaner (Simparica) 174 reports · 1.0% of its reports
Vocalising after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 75 reports · 0.8% of its reports
Vocalising after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) 41 reports · 1.3% of its reports

All reported side effects of Lotilaner in dogs · Medicines most reported with vocalising