Seizures after Lotilaner (Credelio) in dogs

686 reports to the FDA describe seizures in dogs given Lotilaner. That is 6.9% of all reports for this medicine, compared with 4.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

686Reports

88%Marked serious

47%Recovered

10%Died or euthanised

6 daysTypical onset

How soon it started

Same day

135 24%

1–2 days

92 16%

3–7 days

71 13%

1–4 weeks

76 14%

Over a month

186 33%

How the animals did

Recovered

324 47%

Recovered with lasting effects

1 0.1%

Still unwell when reported

140 20%

Died

32 4.7%

Euthanised

37 5.4%

Not known

152 22%

Problems reported at the same time

74 11%

72 10%

69 10%

64 9.3%

61 8.9%

52 7.6%

48 7.0%

35 5.1%

Age of the animals

Under 1 year

119

1–3 years

166

4–7 years

164

8–11 years

130

12+ years

About this medicine

Lotilaner kills fleas and ticks; monthly chewable.

Products with this ingredient include Credelio. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Lotilaner cause seizures in dogs?: 686 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 6 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Seizures with similar medicines

Seizures after Fluralaner (Bravecto) 3,501 reports · 5.1% of its reports
Seizures after Afoxolaner (NexGard) 4,287 reports · 7.5% of its reports
Seizures after Sarolaner (Simparica) 2,972 reports · 18% of its reports
Seizures after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 500 reports · 5.4% of its reports
Seizures after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) 141 reports · 4.6% of its reports

All reported side effects of Lotilaner in dogs · Medicines most reported with seizures